僅用于工業(yè)應(yīng)用或科學(xué)研究,不可用于人類或動物的臨床診斷或治療,非藥用.Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV.Rilpivirine (R278474) 是一種有效和特異性的二芳基嘧啶 (DAPY) 非核苷逆轉(zhuǎn)錄酶抑制劑 (NNRTI)。Rilpivirine 對野生型 HIV (EC50=0.4 nM) 和突變體 (EC50=0.1-2.0 nM) 具有很高的抗病毒活性。Rilpivirine 對 HIV 耐藥性的形成產(chǎn)生了高度的遺傳障礙